Physical examination and clinical investigations are essential components of psychiatric assessment and management. Many medical illnesses present with psychiatric symptoms. A client's mental state often influences the outcome in medical disorders. Many clients with mental illness present with physical symptoms. A comprehensive physical examination by the primary care practitioner is essential, together with routine clinical investigations that include doing a complete blood count; checking electrolytes, fasting blood glucose, liver and thyroid function; and performing urinalysis. Based on the results, the primary care practitioner may order more specific tests or obtain further consultation