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Second-and-third-line antidepressants

Table 2.2: Second and third-line antidepressant medications and doses

Medication Usual daily dose (mg)
Second-line antidepressants  
amitriptyline 100-250
clomipramine 100-250
desipramine 100-250
imipramine 100-250
nortriptyline 75-150
Third-line antidepressants  
phenelzine 30-75
tranylcypromine 20-60


* Use with caution because of dietary restrictions and drug-drug interactions.


TCA = tricyclic antidepressant

MAOI = monoamine oxidase inhibitor