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Second-and-third-line antidepressants

Table 2.2: Second and third-line antidepressant medications and doses

 
Medication Usual daily dose (mg)
Second-line antidepressants  
TCA  
amitriptyline 100-250
clomipramine 100-250
desipramine 100-250
imipramine 100-250
nortriptyline 75-150
Third-line antidepressants  
MAOI*  
phenelzine 30-75
tranylcypromine 20-60

 

* Use with caution because of dietary restrictions and drug-drug interactions.

 

TCA = tricyclic antidepressant

MAOI = monoamine oxidase inhibitor